Movement and positional control of mitochondria and other organelles are coordinated with cell cycle progression in the budding yeast, Saccharomyces cerevisiae. Recent studies have revealed a checkpoint that inhibits cytokinesis when there are severe defects in mitochondrial inheritance. An established checkpoint signaling pathway, the mitotic exit network (MEN), participates in this process. Here, we describe mitochondrial motility during inheritance in budding yeast, emerging evidence for mitochondrial quality control during inheritance, and organelle inheritance checkpoints for mitochondria and other organelles.

A propósito de su reciente visita a Colombia, invitado por la Corte Constitucional y la Universidad de La Sabana, los profesores Leonardo García Jaramillo y Vicente F. Benítez-R. entrevistaron al profesor Jeremy Waldron. Waldron fue Chichele Professor en la Universidad de Oxford, discípulo y contradictor de Dworkin, y es uno de los autores más influyentes del debate teórico político y constitucional contemporáneo. Actualmente es University Professor de la Universidad de New York. La traducción al español de la entrevista (...) es también de Leonardo García Jaramillo y Vicente F. Benítez-R... (shrink)

IntroductionTranscranial magnetic stimulation is a consolidated procedure for the treatment of depression, with several meta-analyses demonstrating its efficacy. Theta-burst stimulation is a modification of TMS with similar efficacy and shorter session duration. The geriatric population has many comorbidities and a high prevalence of depression, but few clinical trials are conducted specifically for this age group. TBS could be an option in this population, offering the advantages of few side effects and no pharmacological interactions. Therefore, our aim is to investigate the (...) efficacy of TBS in geriatric depression.Clinical trial registration[https://clinicaltrials.gov/ct2/], identifier [NCT04842929]. (shrink)

There is an ongoing debate about the meaning of lexical words, i.e., words that contribute with content to the meaning of sentences. This debate has coincided with a renewal in the study of polysemy, which has taken place in the psycholinguistics camp mainly. There is already a fruitful interbreeding between two lines of research: the theoretical study of lexical word meaning, on the one hand, and the models of polysemy psycholinguists present, on the other. In this paper I aim at (...) deepening on this ongoing interbreeding, examine what is said about polysemy, particularly in the psycholinguistics literature, and then show how what we seem to know about the representation and storage of polysemous senses affects the models that we have about lexical word meaning. (shrink)

Este trabajo surge de un diálogo interdisciplinario entre dos tesis doctorales, una de educación y otra de filosofía, que comparten un interés sobre formas emancipadoras y democráticas de pensar con otros y otras en la escuela pública latinoamericana. Desde una perspectiva crítica propia de la filosofía de la educación latinoamericana realizamos un análisis epistemológico sobre las distintas formas de habitar la pregunta dentro de una práctica filosófica con niños y niñas. Tomamos como objeto de estudio una experiencia específica de comunidad (...) de indagación realizada en 2022 en el sur de Mendoza, Argentina. Entramamos herramientas teóricas de Walter Kohan, Paulo Freire y Jacques Rancière con la intención de visibilizar diversas formas de habitar la producción de saberes dentro de dicha comunidad. Proponemos dos nudos problemáticos: por un lado, el orden explicador/embrutecedor a partir de Rancière y, por el otro,la pregunta como afirmación vital a partir de Kohan y Freire. Trabajamos una serie de disonancias en torno a la circulación y a la potencia de la pregunta en la escuela y la educación pública. Finalmente proponemos una síntesis de estas problemáticas en la postulación de una “pregunta niña” como potencia epistémica emancipadora que supone una intimidad con los otros y otras, con las cosas y el mundo abierta desde una igualdad política e intelectual radical. (shrink)

El artículo tiene por objeto analizar la construcción del conocimiento mapuche según el discurso de kimches. Sostenemos que en la educación familiar existe un proceso de construcción de conocimientos propios como un sistema de saberes y contenidos educativos para la formación de personas. La metodología empleada es la investigación educativa. Los resultados parciales muestran una descripción acerca de la lógica de los conocimientos educativos propios, para contextualizar la enseñanza y el aprendizaje de las ciencias en el medio escolar, desde la (...) educación intercultural en contexto mapuche. The aim of this article is to analyze the construction of Mapuche knowledge based on the kimches speech. We argue that within family education, there exists a process of constructing their own knowledge, as a system of knowledge and educational contents for forming individuals. The research methodology applied corresponds to education research. Preliminary results describe the logic of individual educational knowledge from intercultural education in the Mapuche context, so as to contextualize the teaching and learning of Science in schools. (shrink)

An atmosfere of fear seems to surround western culture in the last two or three decades. From it stems a new kind of fear, imaginarially expressed in the fear of collapse event. In this paper, we chart some manifestations of the new fear of collapse in the sphere of cinema and of intelectual academic writings. In the first case, with the emergence of collapse and zombie movies in cultural industry productions; in the second one, in the emergence of civilizational collapse (...) as a theme for historians, systems and complexity cientists, ecologists, peak-oil theorists, economists, social scientists etc. Some possible explanatory hipothesis for the emergency of this fenomenon are conjectured. (shrink)

Le droit applicable à l’exercice de l’autorité parentale a été remanié par la loi du 4 mars 2002. Il existe désormais un statut légal du couple parental, applicable quelle que soit la situation familiale des parents, conditionné par l’établissement du lien de filiation de l’enfant. Ce droit commun est gouverné par un principe supérieur : les père et mère exercent en commun l’autorité parentale. La consécration progressive d’un principe d’autorité parentale conjointe (1970,1987,1993, 2002) est certes un progrès en ce qu’elle (...) invite les parents à s’accorder et à se consulter dans l’exercice de l’autorité parentale, mais l’indifférenciation des situations familiales sur laquelle repose désormais la notion de « coparentalité » est excessive en ce qu’elle conduit à détacher le principe du modèle d’un couple uni. Une autre orientation pourrait être prise : celle consistant à rapprocher du mariage le concubinage avec vie maritale, ce qui supposerait de prendre en la matière le contre-pied de la loi de 1999. L’apport le plus apparent de la loi du 4 mars 2002 est de prévoir tout un arsenal de dispositions de nature à assurer l’effectivité du principe de coparentalité, en particulier les conventions et la résidence alternée. Les conventions marquent, sous l’angle de la notion d’ordre public, l’avènement du pluralisme familial, nouveauté encadrée par un corps de règles de plus en plus tentaculaire. Quant à la résidence alternée, cette modalité présente le défaut majeur d’être désormais légale, ce qui implique sa vocation à s’appliquer à tous. Il serait souhaitable pour cette raison de rétablir dans la loi le principe de la résidence habituelle de l’enfant chez l’un de ses parents et de réserver la résidence alternée à la pratique judiciaire, à titre très exceptionnel et expérimental, pour des enfants en âge de l’assumer. (shrink)

Deals with the topic of causality. This book traces the evolution of causal thinking from antiquity to the present and culminates with a description of five key conditions that must be satisfied to demonstrate a causal effect.

Following some of the main arguments Derrida develops in ‘White Mythology’, in this article I propose an unexplored dialogue between Derrida and Althusser considering the use and the place that each of them gives to metaphor in their philosophical strategies. I give special attention to some rather isolated passages of ‘Elements of Self-Criticism’ and ‘Lenin and Philosophy’, where Althusser, against all evidence, seems to be quite aware of the importance of metaphor and mataphorization in every philosophical practice. As Balibar has (...) argued, contrary to the metaphysical tradition, metaphor would not be the opposite but what anticipates the concept. In this sense, it is possible to observe how Althusser’s work has continuously put into practice – as the singular signature of his theoretical practice – something that I call the ‘detour of metaphor’ as a necessary ‘deviation’ for the production of new concepts. Without any evidence that Althusser may have known Derrida’s essay, I show how Althusser’s own theoretical work, one in which ‘metaphor’ as a philosophical theme appears to be rather anecdotic, is unexpectedly close to Derrida’s own positions concerning the margins of philosophy and its ‘outside’, the relation to the metaphysical tradition, and the importance of strategy in philosophy. (shrink)

Este artículo analiza cómo los modelos de producción y de consumo de los años veinte determinaron la obsesión cultural por la autenticidad. A partir de los análisis que hicieron Benjamin, Adorno y Kracauer se analiza el modo en que la industria cultural favorece la identificación estética con las estrellas de la conocida como sociedad de masas. A continuación, se explica por qué el origen de esta realidad hay que buscarlo en el proyecto literario y político de Rousseau y en el (...) modo en que éste, al mismo tiempo que rehabilita la novela en la institución literaria, asocia virtud moral y pasión natural. (shrink)

This paper argues that satire constitutes a particularly effective strategy for feminist philosophy through an analysis of Simone de Beauvoir’s account of motherhood. Feminists have grappled at length with how to interpret Beauvoir’s focus on the unpleasantness of pregnancy and challenges of motherhood. In this paper, I suggest a new interpretive strategy. My view is that Beauvoir’s disparaging depiction of motherhood cannot be read by the letter; rather, it is an exercise in satire. By overemphasizing its strangeness and difficulty, Beauvoir (...) dethrones motherhood as the pinnacle of feminine existence, transforming it from women’s only possible destiny into a contingent feature of existence. My underlying contention here is that such feminist satirizing speaks to the aims of feminist philosophy more generally: the satirical subversion of our buried assumptions opens the possibility of imagining the world anew. (shrink)

The renewed interest in concepts and their role in psychological theorizing is partially motivated by Machery’s claim that concepts are so heterogeneous that they have no explanatory role. Against this, pluralism argues that there is multiplicity of different concepts for any given category, while hybridism argues that a concept is constituted by a rich common representation. This article aims to advance the understanding of the hybrid view of concepts. First, we examine the main arguments against hybrid concepts and conclude that, (...) even if not successful, they challenge hybridism to find a robust criterion for concept individuation and to show an explanatory advantage for hybrid concepts. Then we propose such a criterion of individuation, which we will call ‘functional stable coactivation’. Finally, we examine the prospects of hybridism to understand what is involved in recent approaches to categorization and meaning extraction. 1 The Heterogeneity of Conceptual Representations2 Two Challenges for Hybrid Concepts: Individuation and Explanation2.1 The coordination criterion2.2 Concepts as constituents of thoughts3 Individuating Hybrids: Functional Stable Coactivation4 The Explanatory Power of Hybrid Concepts4.1 Categorization4.2 Meaning extraction4.2.1 Linguistic comprehension and rich lexical entries4.2.2 Polysemy and hybrid concepts5 Conclusion. (shrink)

This paper presents a blueprint for an ecological cognitive architecture. Ecological psychology, I contend, must be complemented with a story about the role of the CNS in perception, action, and cognition. To arrive at such a story while staying true to the tenets of ecological psychology, it will be necessary to flesh out the central metaphor according to which the animal perceives its environment by ‘resonating’ to information in energy patterns: what is needed is a theory of resonance. I offer (...) here the two main elements of such a theory: a framework and a methodology. (shrink)

In this paper we address the question of what determines the content of our conscious episodes of thinking, considering recent claims that phenomenal character individuates thought contents. We present one prominent way for defenders of phenomenal intentionality to develop that view and then examine ‘sensory inner speech views’, which provide an alternative way of accounting for thought-content determinacy. We argue that such views fare well with inner speech thinking but have problems accounting for unsymbolized thinking. Within this dialectic, we present (...) an account of the nature of unsymbolized thinking that accords with and can be seen as a continuation of the activity of inner speech, while offering a way of explaining thought-content determinacy in terms of linguistic structures and representations. (shrink)

Considering the most recent advances in artificial intelligence and biomechanics, a hypothetical future of physicalism is explored. It is concluded that a rational and sensible extrapolation of present and expected future advances in those two areas will have vast consequences in the physicalist view. In particular, it is also argued that consciousness cannot be defined in a simple general manner, but only understood through the observable and behavioural actions of humans or sufficiently advanced robots, which may be, at some future (...) time, indistinct. This last result is established by applying what we call Plato’s trap, and our main conclusion is a defence of physicalism. It is argued that human beings are robots which soon will be indistinguishable from suitable advanced man-made robots, which will in turn render many philosophical questions and objections to physicalism irrelevant and, in fact, quite similar in sense and importance to some philosophical medieval questions about God, the soul and immortality. (shrink)

Face à la violence, que peut la philosophie? Cette question se pose avec une terrible acuité après les attentats de janvier contre Charlie Hebdo et l'hyper-cacher. Le présent ouvrage prétend y apporter une réponse en prenant du recul et à travers la philo française contemporaine de Sartre à Levinas en passant par Camus, Maurice Merleau-Ponty, Simone Weil, Canguilhem, Cavaillès, Lévi-Strauss, Deleuze, Foucault, Jankélévitch et Derrida. Sartre, c'est à la fois l'être et le néant et toutes les questions politiques de l'après-guerre (...) ; Camus, l'absurde et la révolte avec le refus de la violence ; Merleau-Ponty, la justification du communisme et donc d'une certaine forme de totalitarisme ; Simone Weil, Canguilhem et Cavaillès mettent le pacifisme à l'épreuve et en avant l'expérience de la nécessité ; Lévi-Strauss pose le problème de la violence face à la diversité humaine repensée ; Deleuze confronte la métaphysique à la politique. Foucault souligne l'enfermement intolérable ; Jankélévitch Derrida et Levinas pose le problème de l'éthique et de la métaphysique et de l'impossible pardon face au génocide juif. Ici c'est toute la philosophie c'est-à-dire, l'action et la pensée les oeuvres et les relations, l'histoire et l'actualité qui tentent de répondre à une certaine folie du monde. (shrink)

One big challenge faced by cognitive science is the development of a unified theory that integrates disparate scales of analysis of cognitive phenomena. In this paper, I offer a unified framework that provides a way to integrate neural and behavioral scales of analysis of cognitive phenomena—typically addressed by neuroscience and experimental psychology, respectively. The framework is based on the concept of resonance originated in ecological psychology and aims to be the foundation for a unified theory for radical embodiment; that is, (...) a unified theory for that dissident part of cognitive science that shares a methodological commitment to dynamic systems theory and remains skeptical about the adequacy of mechanism and representationalism as the guiding ideas in the field. In the course of my presentation, I analyze different issues regarding the requirements and constraints unification poses to radical embodiment. (shrink)

Resumo Este artigo procura apresentar e discutir tentativas recentes em filosofia social de analisar e interpretar o capitalismo, a partir de uma perspectiva praxeológica. O practice turn em teoria social procurou superar o dualismo entre agência e estrutura, ou entre ação e sistema, por meio da noção de prática social. Seria possível então interpretar o capitalismo como um tipo especifico de prática social? Para tentar encaminhar essa questão, explicita-se brevemente, em um primeiro momento, em que consiste o practice turn em (...) teoria social. Num segundo momento, analisa-se e se discute a proposta de Rahel Jaeggi de conceber a economia como uma rede de práticas sociais. Em seguida, expõe-se e se avalia a tentativa de Christian Lotz em ver, no dinheiro, a chave para compreender aquilo que ele chama de esquema capitalista. Por fim, conclui-se, chamando a atenção para os potenciais e desafios ligados ao empreendimento de interpretar o capitalismo em função de uma teoria da prática, sugerindo que um aprofundamento na análise da imaginação especificamente capitalista, vinculando-a com a típica plasticidade e diversidade do capitalismo, possa ajudar a avançar nesse campo.This paper aims to present and discuss recent attempts in social philosophy to analyze and interpret capitalism from a praxeological perspective. The practice turn in social theory sought to overcome the dualism between agency and structure, or between action and system, through the notion of social practice. Is it then possible to interpret capitalism as a specific type of social practice? To try to address this question, I briefly introduce, in a first moment, the practice turn in social theory. In a second moment, I analyze and discuss Rahel Jaeggi’s proposal to conceive the economy as a network of social practices. I then explain and evaluate Christian Lotz’s attempt to see money as the key to understanding what he names as “the capitalist schema”. Finally, I conclude by drawing attention to the potentials and challenges of interpreting capitalism as a social practice, suggesting that a deeper analysis of specifically capitalist imagination, linking it with the typical plasticity and diversity of capitalism, may help to move forward in this field. (shrink)

According to a model defended by some authors, dispositional concepts can be legitimately used in causal explanations, although such a use is not necessary. I argue, however, that there is a kind of use of dispositions in explanations that does not fall within this model: we will miss some explanations if we forsake dispositional concepts and explanations.

In this paper we discuss a phenomenon we call perspectival plurality, which has gone largely unnoticed in the current debate between relativism and contextualism about predicates of personal taste. According to perspectival plurality, the truth value of a sentence containing more than one PPT may depend on more than one perspective. Prima facie, the phenomenon engenders a problem for relativism and can be shaped into an argument in favor of contextualism. We explore the consequences of perspectival plurality in depth and (...) assess several possible responses on behalf of advocates of relativism. (shrink)

Using the method of Descriptive Experience Sampling, some subjects report experiences of thinking that do not involve words or any other symbols [Hurlburt, R. T., and C. L. Heavey. 2006. Exploring Inner Experience. Amsterdam: John Benjamins; Hurlburt, R. T., and S. A. Akhter. 2008. “Unsymbolized Thinking.” Consciousness and Cognition 17 : 1364–1374]. Even though the possibility of this unsymbolized thinking has consequences for the debate on the phenomenological status of cognitive states, the phenomenon is still insufficiently examined. This paper analyzes (...) the main properties of unsymbolized thinking and advances an explanation of its origin. According to our analysis, unsymbolized thoughts appear as propositional states, that is, they are experienced as compositional conceptual phenomena, with semantic and syntactic features analogous to those of the contents of utterances. Based on this characterization, we hypothesize that UT is continuous with the activity of inner speech, in particular, it i... (shrink)

Organization figures centrally in the understanding of biological systems advanced by both new mechanists and proponents of the autonomy framework. The new mechanists focus on how components of mechanisms are organized to produce a phenomenon and emphasize productive continuity between these components. The autonomy framework focuses on how the components of a biological system are organized in such a way that they contribute to the maintenance of the organisms that produce them. In this paper we analyze and compare these two (...) accounts of organization and argue that understanding biological organisms as cohesively integrated systems benefits from insights from both. To bring together the two accounts, we focus on the notions of control and regulation as bridge concepts. We start from a characterization of biological mechanisms in terms of constraints and focus on a specific type of mechanism, control mechanisms, that operate on other mechanisms on the basis of measurements of variables in the system and its environment. Control mechanisms are characterized by their own set of constraints that enable them to sense conditions, convey signals, and effect changes on constraints in the controlled mechanism. They thereby allow living organisms to adapt to internal and external variations and to coordinate their parts in such a manner as to maintain viability. Because living organisms contain a vast number of control mechanisms, a central challenge is to understand how they are themselves organized. With the support of examples from both unicellular and multicellular systems we argue that control mechanisms are organized heterarchically, and we discuss how this type of control architecture can, without invoking top-down and centralized forms of organizations, succeed in coordinating internal activities of organisms. (shrink)

Desde el retorno de la democracia en Chile, la alianza política que alcanzó el gobierno consolidó sus posiciones de poder e influencia sin conocer por 20 años alternancia o grandes cambios en sus formas de gestión. Aunque el control del gobierno cambió a una coalición diferente en 2010, la agrupación previa continúa existiendo y posee una significativa representación en el parlamento. ¿Qué expresa tal estabilidad? El argumento principal en este artículo es que un origen social similar de los parlamentarios unido (...) a una interacción social frecuente reduce el dramatismo de las diferencias ideológicas haciendo así más probable las transformaciones políticas o el cambio del grupo en el poder. El análisis considera datos sociodemográficos de los parlamentarios, así como datos de redes sociales de una muestra 37 parlamentarios en ejercicio y 20 que lo hicieron entre 1990 y 2004. El origen social de los parlamentarios corresponde en forma creciente a un medio social similar, caracterizado por escolarización en establecimientos privados y universidades, alcanzando un status socioeconómico relativamente alto. El mapa de sus redes sociales muestra que el clivaje ideológico entre dictadura y democracia alcanzó también las relaciones sociales, estableciendo gran distancia social entre los políticos que hoy dominan la escena. El mapa permite apreciar también un nuevo campo político socialmente más diverso, en el cual tienen relevancia políticos más jóvenes, líderes regionales y la universidad como espacio de encuentro entre políticos e intelectuales. (shrink)

La figura de Walter Benjamin ha venido adquiriendo en los últimos años una inesperada actualidad. Su contribución al pensamiento de nuestro siglo aparece hoy como una intervención singular e irrepetible, producto de una encrucijada cultural patentemente determinada por la conciencia de crisis generalizada por la modernidad. En este contexto, la presente investigación trata de ofrecer una aproximación informativa y ajustada al conjunto de la obra de Benjamin, en una lectura efectuada desde el punto de vista de la Estética. En consecuencia, (...) el libro recorre puntualmente la sinuosa trayectoria de Benjamin desde sus tempranos escritos juveniles, pasando por su maduración crítica en sus trabajos en torno al universo romántico y el barroco, hasta su conversión al materialismo histórico y su explosiva dispersión en la obra de los Pasajes. (shrink)

O projeto emancipatório moderno estabelece uma concepção otimista de desenvolvimento científico e social. Os filósofos Immanuel Kant e Karl Marx, de modo distinto, levam ao ápice tal projeto emancipatório, o primeiro, ancorado numa concepção de sujeito transcendental capaz de estabelecer verdade e validade universal, o segundo, ancorado na categoria de trabalho desenvolvida em sua doutrina do materialismo histórico. A partir do século XIX, filósofos como Nietzsche, Heidegger e Adorno/Horkheimer põem sob suspeita tal projeto ao demonstrar seus fundamentos não metafísicos. Tais (...) críticas expurgam as pretensões totalitárias do projeto emancipatório moderno, e nos remetem à sua revisão. O filósofo alemão Jurgen Habermas, considerando as críticas elaboradas pelos filósofos da suspeita, vai buscar reconstruir o projeto emancipatório moderno a partir de bases pós-metafísicas. A raiz de tal reconstrução está em Trabalho e Interação. Notas sobre a filosofia do espírito de Hegel em Jena, na qual Habermas promove o confronto da filosofia hegeliana com o pensamento de Kant e Marx, possibilitando a revisão destes. Nessa revisão Habermas desenvolve os conceitos de trabalho e interação, que ao mesmo tempo fundamentam sua crítica à tecnocracia e lançam os pilares para a posterior elaboração da Teoria da Ação Comunicativa. (shrink)

According to an increasing number of authors, the best, if not the only, argument in favour of physicalism is the so-called 'overdetermination argument'. This argument, if sound, establishes that all the entities that enter into causal interactions with the physical world are physical. One key premise in the overdetermination argument is the principle of the causal closure of the physical world, said to be supported by contemporary physics. In this paper, I examine various ways in which physics may support the (...) principle, either as a methodological guide or as depending on some other laws and principles of physics. (shrink)

Living organisms act as integrated wholes to maintain themselves. Individual actions can each be explained by characterizing the mechanisms that perform the activity. But these alone do not explain how various activities are coordinated and performed versatilely. We argue that this depends on a specific type of mechanism, a control mechanism. We develop an account of control by examining several extensively studied control mechanisms operative in the bacterium E. coli. On our analysis, what distinguishes a control mechanism from other mechanisms (...) is that it relies on measuring one or more variables, which results in setting constraints in the control mechanism that determine its action on flexible constraints in other mechanisms. In the most basic arrangement, the measurement process directly determines the action of the control mechanism, but in more complex arrangements signals mediate between measurements and effectors. This opens the possibility of multiple responses to the same measurement and responses based on multiple measurements. It also allows crosstalk, resulting in networks of control mechanisms. Such networks integrate the behaviors of the organism but also present a challenge in tailoring responses to particular measurements. We discuss how integrated activity can still result in differential, versatile, responses. (shrink)

This text goes as a reflection on the uses of the concept of mimesis as the core of Adorno’s thought. It starts with the proposals of the Dialectic of the Enlightenment, and then refers them to the way in which they reappear in the Aesthetic Theory, distinguishing the role of mimesis in he process of the production of the work and in that of its reception, both in art as in mass culture. Finally, it points to the possibility of enriching (...) the concept by connecting it with Benjamin. Adorno, mimesis, reception, culture industry, Benjamin. Resumen El texto se presenta como una reflexión en torno a los usos del concepto de mímesis como núcleo del pensamiento de Adorno. Se parte de los planteamientos de la Dialéctica de la Ilustración, para luego remitirlos a la manera en que reaparecen en la Teoría estética, distinguiendo el papel de la mímesis en el proceso de la producción de la obra y en el de su recepción, tanto en el arte como en la cultura de masas. Finalmente, se apunta a la posibilidad de enriquecer el concepto conectándolo con Benjamin. (shrink)

Teaching mathematics and improving mathematics competence are pending subjects within our educational system. The PEIM (Programa Evolutivo Instruccional para Matemáticas), a constructivist intervention program for the improvement of mathematical performance, affects the different agents involved in math learning, guaranteeing a significant improvement in students’ performance. The program is based on the following pillars: (a) students become the main agents of their learning by constructing their own knowledge; (b) the teacher must be the guide to facilitate and guarantee such a construction (...) by being a great connoisseur of the fundamental aspects of the development of the child’s mathematical thinking; (c) the mathematical contents must be sequenced in terms of the complexity and significance for the student as well as contextualized at all times; and (d) the classroom must have a constructivist climate highlighting cooperative work among students. The implementation of PEIM along with the empirical evaluation conducted in several centers in Madrid and Zaragoza (Spain) confirm how students improve their mathematical competence. Both first- and second-grade students in elementary education were far more effective in solving problems, highlighting the use of more advanced strategies in their resolution and a lower incidence of conceptual errors. Moreover, it was possible to verify how the students proving greater difficulty, experienced an evolution in learning similarly to those who did not present it. The program provides customized education to allow the teacher to know at all times how he should be more influential on the students’ learning through mathematical profiles. Both teaching practice and teachers were observed, being that of the experimental group more prone to analyzing processes and allowing the construction of knowledge by students, due to their psycho-developmental training. As a result, we found several improvements through the implementation of the program that may serve, for upcoming years, as a basis for the necessary changes in the teaching of mathematics. (shrink)

ABSTRACT This paper aims at examining the way in which Rahel Jaeggi’s conception of forms of life as inert bundles of practices is connected to the problem of the possibility of an immanent critique of life forms, that is, of a kind of analysis that is both internal and transformative. In the first part, my contention will be that understanding practices in terms of conventions makes it difficult to admit of internal criticisms of them. Jaeggi’s account of immanent critique, as (...) argued in the second part, tries to differentiate practices from social conventions by maintaining that transformations of life forms can be seen as the result of episodes of crises ignited by the inability to cope with “second order” problems. I maintain that, unless one is willing to postulate something like an absolute telos dictating the historical sequence that forms of life must follow, the way in which forms of life solve second order problems displays some conventional features preventing any quick assimilation to the paradigm of immanent critique. This circumstance, as argued in the third section of my presentation, poses an obstacle to Jaeggi’s project of an immanent critique of life forms. (shrink)

In this article, an epistemological and ontological view of Statistical Mechanics is presented. The author believes that this is a clear-cut example that can prove to be useful as a resource material for teachers, and also, a clear pedagogical material for science students when taking courses of Philosophy of Science. Statistical Mechanics is a regular course on most science and engineering programs, we believe that this fact facilitate the understanding of the philosophical discussion here presented.

Biological regulation is what allows an organism to handle the effects of a perturbation, modulating its own constitutive dynamics in response to particular changes in internal and external conditions. With the central focus of analysis on the case of minimal living systems, we argue that regulation consists in a specific form of second-order control, exerted over the core regime of production and maintenance of the components that actually put together the organism. The main argument is that regulation requires a distinctive (...) architecture of functional relationships, and specifically the action of a dedicated subsystem whose activity is dynamically decoupled from that of the constitutive regime. We distinguish between two major ways in which control mechanisms contribute to the maintenance of a biological organisation in response to internal and external perturbations: dynamic stability and regulation. Based on this distinction an explicit definition and a set of organisational requirements for regulation are provided, and thoroughly illustrated through the examples of bacterial chemotaxis and the lac-operon. The analysis enables us to mark out the differences between regulation and closely related concepts such as feedback, robustness and homeostasis. (shrink)

Despite numerous and increasing attempts to define what life is, there is no consensus on necessary and sufficient conditions for life. Accordingly, some scholars have questioned the value of definitions of life and encouraged scientists and philosophers alike to discard the project. As an alternative to this pessimistic conclusion, we argue that critically rethinking the nature and uses of definitions can provide new insights into the epistemic roles of definitions of life for different research practices. This paper examines the possible (...) contributions of definitions of life in scientific domains where such definitions are used most (e.g., Synthetic Biology, Origins of Life, Alife, and Astrobiology). Rather than as classificatory tools for demarcation of natural kinds, we highlight the pragmatic utility of what we call operational definitions that serve as theoretical and epistemic tools in scientific practice. In particular, we examine contexts where definitions integrate criteria for life into theoretical models that involve or enable observable operations. We show how these definitions of life play important roles in influencing research agendas and evaluating results, and we argue that to discard the project of defining life is neither sufficiently motivated, nor possible without dismissing important theoretical and practical research. (shrink)

Charles Travis has been forcefully arguing that meaning does not determine truth-conditions for more than two decades now. To this end, he has devised ingenious examples whereby different utterances of the same prima facie non-ambiguous and non-indexical expression type have different truth-conditions depending on the occasion on which they are delivered. However, Travis does not argue that meaning varies with circumstances; only that truth-conditions do. He assumes that meaning is a stable feature of both words and sentences. After surveying some (...) of the explanations that semanticists and pragmaticians have produced in order to account for Travis cases, I propose a view which differs substantially from all of them. I argue that the variability in the truth-conditions that an utterance type can have is due to meaning facts alone. To support my argument, I suggest that we think about the meanings of words (in particular, the meanings of nouns) as rich conceptual structures; so rich that the way in which a property concept applies to an object concept is not determined. (shrink)